PRIMING WITH L-DOPA DIFFERENTLY AFFECTS DYNORPHIN AND SUBSTANCE-P MESSENGER-RNA LEVELS IN THE STRIATUM OF 6-HYDROXYDOPAMINE-LESIONED RATS AFTER CHALLENGE WITH DOPAMINE D1-RECEPTOR AGONIST

Authors
VANDEWITTE SV DRUKARCH B STOOF JC VOORN P
Citation
Sv. Vandewitte et al., PRIMING WITH L-DOPA DIFFERENTLY AFFECTS DYNORPHIN AND SUBSTANCE-P MESSENGER-RNA LEVELS IN THE STRIATUM OF 6-HYDROXYDOPAMINE-LESIONED RATS AFTER CHALLENGE WITH DOPAMINE D1-RECEPTOR AGONIST, Molecular brain research, 61(1-2), 1998, pp. 219-223
Citations number
22
Categorie Soggetti
Neurosciences
Journal title
Molecular brain research → ACNP
ISSN journal
0169328X
Volume
61
Issue
1-2
Year of publication
1998
Pages
219 - 223
Database
ISI
SICI code
0169-328X(1998)61:1-2<219:PWLDAD>2.0.ZU;2-7
Abstract
In unilaterally 6-hydroxydopamine-lesioned rats, potentiation of D1-ag onist-induced turning behavior by priming with L-DOPA was correlated w ith changes in striatal neuropeptide mRNA levels. In non-primed rats, administration of the D1-agonist SKF-38393 markedly increased dynorphi n and substance P mRNA levels in the lesioned striatum. Priming with L -DOPA dissociated the response of the two neuropeptides to the D1-agon ist, with higher dynorphin and reduced substance P mRNA levels. (C) 19 98 Elsevier Science B.V. All rights reserved.