EFFECT OF CHRONIC HALOPERIDOL TREATMENT ON SYNAPTIC PROTEIN MESSENGER-RNAS IN THE RAT-BRAIN

Authors
NAKAHARA T NAKAMURA K TSUTSUMI T HASHIMOTO K HONDO H HISATOMI S MOTOMURA K UCHIMURA H
Citation
T. Nakahara et al., EFFECT OF CHRONIC HALOPERIDOL TREATMENT ON SYNAPTIC PROTEIN MESSENGER-RNAS IN THE RAT-BRAIN, Molecular brain research, 61(1-2), 1998, pp. 238-242
Citations number
35
Categorie Soggetti
Neurosciences
Journal title
Molecular brain research → ACNP
ISSN journal
0169328X
Volume
61
Issue
1-2
Year of publication
1998
Pages
238 - 242
Database
ISI
SICI code
0169-328X(1998)61:1-2<238:EOCHTO>2.0.ZU;2-J
Abstract
Chronic haloperidol treatment caused significant decreases in the leve ls of synaptotagmin I and IV, synaptobrevin II, syntaxin 1A and Rab 3A mRNAs in the nucleus accumbens but not in the prefrontal cortex media l field, striatum, substantia nigra and ventral tegmental area. No sig nificant changes in SNAP 25 and synaptophysin mRNA levels were observe d in any brain region examined. The reduced expression of synaptic pro teins may be related to haloperidol-induced depolarization block of me solimbic dopamine neurons. (C) 1998 Elsevier Science B.V. All rights r eserved.