DNA-REPAIR AND CARCINOGENESIS - UNIVERSAL MECHANISMS OF DNA-REPAIR INPROKARYOTES AND EUKARYOTES, AND CONSEQUENCES OF THEIR DAMAGE IN HUMANS

The cells of prokaryotes (Escherichia coil) and lower (Saccharomyces c erevisiae) and higher (Homo sapiens) eukaryotes possess DNA repair sys tems, which, by complementing one another, ensure the accuracy of repr oduction and storage of genetic information. Most of these systems are universal, as they are functionally similar in prokaryotes and eukary otes. Inherited distortions of cell repair systems in humans result in severe inborn disorders and/or predisposition to cancer.