EXTRAMEDULLARY T-LYMPHOBLASTIC TRANSFORMATION OF CHRONIC MYELOID-LEUKEMIA OCCURRING AFTER DOUBLE ALLOGENEIC TRANSPLANTATION

The clinical course of chronic myeloid leukaemia (CML) is characterise d by a chronic phase followed by an acute phase or blast crisis, Lymph oid transformation accounts for 20-30% of such events, with the majori ty of cases being of B cell origin. Extramedullary transformation occu rs in approximately 10% of cases. We report a case of T cell lymphobla stic transformation in CML presenting as an extramedullary mass after allogeneic stem cell transplant. This case supports the growing eviden ce that CML arises in the pluripotent stem cell.