RHINOCEREBRAL MUCORMYCOSIS FOLLOWING DONOR LEUKOCYTE INFUSION - SUCCESSFUL TREATMENT WITH LIPOSOMAL AMPHOTERICIN-B AND SURGICAL DEBRIDEMENT

A 24-year-old male developed cytogenetic relapse of chronic myeloid le ukemia (CML) four years after allogeneic BMT, After a year of treatmen t with IFN-cu, he achieved a partial cytogenetic response. Treatment w ith donor leukocyte infusions (DLI) was given (total dose 1 x 10(8) T lymphocytes/kg), Two months later, he developed acute GVHD (skin and l iver), that improved with CsA and methylprednisolone and resulted in c ytogenetic remission,vith complete donor chimerism, One month later he developed rhinocerebral mucormycosis and was successfully treated wit h surgical debridement and liposomal amphotericin B (total dose 12 g), This is the first case of mucormycosis described after DLI.