ADAPALENE 0.1-PERCENT GEL HAS LOW SKIN IRRITATION POTENTIAL EVEN WHENAPPLIED IMMEDIATELY AFTER WASHING

The purpose of this study was to evaluate the difference, if any, in f acial skin tolerance of adapalene 0.1% gel applied immediately after w ashing, compared to delayed application as recommended for the other t opical retinoids: tretinoin and isotretinoin. Twenty-five acne patient s with mild to moderate acne vulgaris were included in this intra indi vidual randomized comparison study where adapalene 0.1% gel was applie d immediately after washing on one half of the face and 20-30 min afte r washing on the contralateral half-face, for 22 consecutive days. No difference between the two regimens was detected by the investigator o r by 21 of the 22 patients who completed the study, It was concluded t hat application of adapalene gel 0.1% is well tolerated even when appl ied immediately after washing.