COMPARISON OF ADAPALENE 0.1-PERCENT SOLUTION AND TRETINOIN 0.025-PERCENT GEL IN THE TOPICAL TREATMENT OF ACNE-VULGARIS

A multicentre study was conducted to compare clinical safety and effic acy of adapalene 0.1% solution and tretinoin 0.025% gel, both topical treatments for acne, in a once-daily dosage regimen for 12 weeks. A to tal of 297 patients were enrolled by eight investigators in this rando mized, investigator-masked study in a parallel group design. An open l abel period using adapalene followed this study to assess the long-ter m safety of adapalene solution. Adapalene and tretinoin proved to be c linically and statistically effective in treating acne by reducing inf lammatory (47% and 50%, respectively) and non-inflammatory lesions (57 % and 54%) as compared to baseline. When comparing patients who had 75 % or greater improvement in open comedones, adapalene was shown to be significantly more effective than tretinoin. No serious adverse event was reported during this study, including during the long-term period. The reactions that occurred were similar between treatments, i.e, bur ning, pruritus, scaling, dryness and erythema.