EFFECTS OF NEUROTROPIN ON HYPERALGESIA AND ALLODYNIA IN MONONEUROPATHIC RATS

Neurotropin is commonly used in Japan for the treatment of chronic pai n. Using a rat model, we evaluated the effect of neurotropin on a unil ateral peripheral mononeuropathy produced by placing loose ligatures a round the sciatic nerve. The effect of neurotropin upon the resultant hyperalgesia and mechanical allodynia was assessed using the Ugo Basil e Plantar test and von Frey hairs test, respectively. Neurotropin redu ced thermal hyperalgesia and produced an early recovery from hyperalge sia in a dose-dependent manner. No significant reduction in mechanical allodynia, however, was noted under the tested condition. A possibili ty of differential drug sensitivity for thermal hyperalgesia and mecha nical allodynia was indicated in this model, although the reason still remain elusive.