EFFECT OF TERGURIDE ON INSULIN BINDING, INSULINEMIA, GLUCOSE-TOLERANCE AND HYPERLIPEMIA IN LEAN SHR KOLETSKY RATS

Glucose tolerance, insulin binding to erythrocytes, insulinaemia, plas ma total cholesterol, plasma triglycerides, weight of fat pads, food c onsumption and body weight changes were studied in genetically hyperte nsive lean Koletsky rats. Long-term treatment with dopaminergic agonis t terguride (0.2 mg/kg/day) normalized glucose tolerance and increased the percentage of bound insulin to erythrocytes in both sexes. Tergur ide decreased insulinaemia, cholesterolaemia, fat pads and body weight only in female rats. Food consumption was not influenced by terguride over the injection period.