To review evidence that psychological factors affect the course of phy
sical illness three areas are examined: epidemiological evidence showi
ng the levels of psychiatric disturbance co-morbid with physical illne
ss; health services research showing the burden of disease and care as
sociated with this co-morbidity; randomised, controlled trials of psyc
hological interventions in cancer, myocardial infarction and irritable
bowel syndrome. There is substantial psychiatric co-morbidity with ph
ysical illness which is associated with increased disability, mortalit
y and utilisation of health-care resources (primary care visits, hospi
talization, length of hospital stay, cost). A small number of controll
ed intervention studies have shown the efficacy of psychological inter
ventions to prolong survival in cancer and myocardial infarction, and
to improve symptomatology in irritable bowel syndrome and other chroni
c somatizing conditions. Psychological factors do significantly affect
outcomes of physical illness. The role of psychological treatments, a
longside somatic therapies, needs further study.