PROLACTIN AND GROWTH-HORMONE SIGNAL-TRANSDUCTION IN LYMPHOHEMATOPOIETIC CELLS

The peptide hormones, prolactin (PRL) and growth hormone (GH), are kno wn to regulate numerous target tissues. Among such targets are cells o f the immune system, including T cells, B cells, macrophages and natur al killer cells. We have cloned a panel of PRL- and GH-inducible T cel l genes for use in studies to understand how these hormones through th e expression of these genes modulate the biology of immune function ce lls. This article focuses on the signalling pathways emanating from th e PRL receptor (PRL-R) and GK receptor (GH-R), and the expression of P RL-inducible target genes.