DNA-END-JOINING - FROM YEAST TO MAN

Authors
CRITCHLOW SE JACKSON SP
Citation
Se. Critchlow et Sp. Jackson, DNA-END-JOINING - FROM YEAST TO MAN, Trends in biochemical sciences, 23(10), 1998, pp. 394-398
Citations number
50
Categorie Soggetti
Biology
Journal title
Trends in biochemical sciences → ACNP
ISSN journal
09680004
Volume
23
Issue
10
Year of publication
1998
Pages
394 - 398
Database
ISI
SICI code
0968-0004(1998)23:10<394:D-FYTM>2.0.ZU;2-Y
Abstract
DNA non-homologous end-joining (NHEJ) is a crucial process that has be en conserved highly throughout eukaryotic evolution. At its heart is a multiprotein complex containing the KU70-KU80 heterodimer. Recent wor k has identified additional proteins involved in this pathway, providi ng insights into the mechanism of NHEJ and revealing exciting links wi th the control of transcription, telomere length and chromatin structu re.