GABAPENTIN - ANTIEPILEPTIC MECHANISM OF ACTION

Authors
KELLY KM
Citation
Km. Kelly, GABAPENTIN - ANTIEPILEPTIC MECHANISM OF ACTION, Neuropsychobiology, 38(3), 1998, pp. 139-144
Citations number
58
Categorie Soggetti
Neurosciences,Psychology,Psychiatry
Journal title
Neuropsychobiology → ACNP
ISSN journal
0302282X
Volume
38
Issue
3
Year of publication
1998
Pages
139 - 144
Database
ISI
SICI code
0302-282X(1998)38:3<139:G-AMOA>2.0.ZU;2-D
Abstract
Gabapentin is an antiepileptic drug used in the treatment of partial a nd generalized tonic-clonic seizures. Its antiepileptic mechanism of a ction is not known. The transport of gabapentin across membranes and i ts demonstrated effects on voltage-gated ion channels (sodium, calcium ), presynaptic mechanisms that can enhance GABAergic inhibition, and l igand-gated ion channels (GABA receptors and glutamate receptors) are reviewed.