YUA001, A NOVEL ALDOSE REDUCTASE INHIBITOR ISOLATED FROM ALKALOPHILICCORYNEBACTERIUM SP. YUA25 - I - TAXONOMY, FERMENTATION, ISOLATION ANDCHARACTERIZATION

Authors
BAHN YS PARK JM BAI DH TAKASE S YU JH
Citation
Ys. Bahn et al., YUA001, A NOVEL ALDOSE REDUCTASE INHIBITOR ISOLATED FROM ALKALOPHILICCORYNEBACTERIUM SP. YUA25 - I - TAXONOMY, FERMENTATION, ISOLATION ANDCHARACTERIZATION, Journal of antibiotics, 51(10), 1998, pp. 902-907
Citations number
11
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology,"Biothechnology & Applied Migrobiology",Immunology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
51
Issue
10
Year of publication
1998
Pages
902 - 907
Database
ISI
SICI code
0021-8820(1998)51:10<902:YANARI>2.0.ZU;2-G
Abstract
YUA001 is a novel aldose reductase inhibitor produced from alkalophili c Corynebacterium sp. YUA25 isolated from soil. YUA001 was purified fr om the supernatant of culture broth by successive silica gel column ch romatography, Sephadex LH20-100 gel column chromatography, and HPLC. F rom instrumental analysis, molecular formula of YUA001 is C13H19NO2 an d its molecular weight is 221. It exhibits potent aldose reductase inh ibition activity and has no antimicrobial activity against some Gram-p ositive or Gram-negative bacteria, fungi and yeast.