A NEW ANTITUMOR ANTIBIOTIC, BE-19412A, PRODUCED BY A STREPTOMYCETE

Authors
TSUKAMOTO M NAKAJIMA S ARAKAWA H SUGIURA Y SUZUKI H HIRAYAMA M KAMIYA S TESHIMA Y KONDO H KOJIRI K SUDA H
Citation
M. Tsukamoto et al., A NEW ANTITUMOR ANTIBIOTIC, BE-19412A, PRODUCED BY A STREPTOMYCETE, Journal of antibiotics, 51(10), 1998, pp. 908-914
Citations number
8
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology,"Biothechnology & Applied Migrobiology",Immunology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
51
Issue
10
Year of publication
1998
Pages
908 - 914
Database
ISI
SICI code
0021-8820(1998)51:10<908:ANAABP>2.0.ZU;2-3
Abstract
A new antitumor substance, designated BE-19412A, was isolated from the culture broth of Streptomyces sp. A19412. The active principle was ex tracted from the mycelium by methanol and purified by Silica gel and S ephadex LH-20 column chromatographies. BE-19412B was prepared by methy lation of BE-19412A. BE-19412A and B exhibited cytotoxic activity agai nst murine and human tumor cell lines. BE-19412A prolonged the surviva l of CDF, mice bearing i.p. implanted Ehrlich carcinoma cells.