GLUCOSYLQUESTIOMYCIN, A NOVEL ANTIBIOTIC FROM MICROBISPORA SP. TP-A0184 - FERMENTATION, ISOLATION, STRUCTURE DETERMINATION, SYNTHESIS AND BIOLOGICAL-ACTIVITIES

Authors
IGARASHI Y TAKAGI K KAJIURA T FURUMAI T OKI T
Citation
Y. Igarashi et al., GLUCOSYLQUESTIOMYCIN, A NOVEL ANTIBIOTIC FROM MICROBISPORA SP. TP-A0184 - FERMENTATION, ISOLATION, STRUCTURE DETERMINATION, SYNTHESIS AND BIOLOGICAL-ACTIVITIES, Journal of antibiotics, 51(10), 1998, pp. 915-920
Citations number
5
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology,"Biothechnology & Applied Migrobiology",Immunology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
51
Issue
10
Year of publication
1998
Pages
915 - 920
Database
ISI
SICI code
0021-8820(1998)51:10<915:GANAFM>2.0.ZU;2-S
Abstract
Glyucosylquestiomycin, a novel N-glucopyranoside of questiomycin A, wa s isolated from the culture broth of Microbispora sp. TP-A0184. The ab solute configuration of the sugar was determined as D-configuration by chemical synthesis. The new antibiotic showed antibacterial activity against Gram-positive and -negative bacteria and yeasts and cytotoxic activity against U937 cells.