A NEW ANTI-MRSA ANTIBIOTIC COMPLEX, WAP-8294A - I - TAXONOMY, ISOLATION AND BIOLOGICAL-ACTIVITIES

Authors
KATO A NAKAYA S KOKUBO N AIBA Y OHASHI Y HIRATA H FUJII K HARADA K
Citation
A. Kato et al., A NEW ANTI-MRSA ANTIBIOTIC COMPLEX, WAP-8294A - I - TAXONOMY, ISOLATION AND BIOLOGICAL-ACTIVITIES, Journal of antibiotics, 51(10), 1998, pp. 929-935
Citations number
11
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology,"Biothechnology & Applied Migrobiology",Immunology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
51
Issue
10
Year of publication
1998
Pages
929 - 935
Database
ISI
SICI code
0021-8820(1998)51:10<929:ANAACW>2.0.ZU;2-B
Abstract
WAP-8294A, produced by Lysobacter sp., is a complex consisting of wate r soluble depsipeptide antibiotics. It was further purified by column chromatographies and HPLC, and 19 components were obtained. WAP-8294A2 , a major component, and minor components Al, A4, Ax8, Ax9 and Ax13 we re active against Gram-positive bacteria, in particular, methicillin-r esistant Staphylococcus aureus (MRSA) in vitro. WAP-8294A2 was highly active in vivo in mice against the systemic infection of MRSA.