G. Champsaur et al., LONG-TERM CLINICAL AND HEMODYNAMIC EVALUATION OF PORCINE VALVED CONDUITS IMPLANTED FROM THE RIGHT VENTRICLE TO THE PULMONARY-ARTERY, Journal of thoracic and cardiovascular surgery, 116(5), 1998, pp. 793-803
Objective: This retrospective study was initiated to evaluate the long
-term results of valved prosthetic conduits implanted in the right ven
tricular outflow tract in patients with complex ventricular-pulmonary
discontinuity, Methods: A cohort of 103 patients out of 127 (24 early
deaths, 19%) operated on between 1973 and 1996 with porcine valved con
duits was available for evaluation, with a follow-up ranging from 1 to
21.6 years (mean follow-up 8.4 +/- 6 years). A total of 74 hemodynami
c studies were performed after the operation, 50 patients having under
gone at feast 1 cardiac catheterization during the follow-up period. R
esults: There were 16 late deaths, and the actuarial survivals, includ
ing early mortality, were 72.9% +/- 4% at 5 years, 63.1% +/- 5% at 10
years, and 58.2% +/- 5% at 15 years, at which time 20 patients were st
ill available for review and exposed to the risk of dying. The mean pe
ak systolic gradient across the right ventricular outflow tract was pl
otted as a function of time, showing a gradual increase and a signific
ant step-up after the eighth year, from 43 +/- 36 to 69 +/- 19 mm Hg (
P < .005), Reoperation was required for progressive conduit obstructio
n between 1.1 and 17.7 years after implantation (mean 7.4 +/- 4.8 year
s) in 25 patients (24%, 70% CL 15%-33%),,vith generally very few sympt
oms, or for residual ventricular septal defect in 3 patients. Freedom
from reoperation was 79.5% +/- 5% at 10 years and 65.8% +/- 7% at 15 y
ears. Conclusions: Porcine conduits may represent a valuable alternati
ve to biologic substitutes with similar long-term results. Given the f
ew symptoms, progressive Conduit stenosis after the eighth postoperati
ve year imposes a yearly noninvasive patient evaluation during the fol
low-up.