The National institute of Occupational Safety and Health (NIOSH) has e
stablished recommended exposure limits of 25 parts per million (ppm) a
s a time-weighted average for nitrous oxide and a ceiling of 2 ppm for
volatile anesthetics. We quantified exposure of postanesthetic nurses
to exhaled anesthetic gases. This study was conducted in the postanes
thesia care unit (PACU) of a medium-sized hospital. PACU air exchanges
averaged 8 vol/h; however, much of this air was recirculated. We eval
uated 50 adults anesthetized with either isoflurane (n = 19) or desflu
rane (n = 31). Roughly half the patients were tracheally extubated in
the operating room, whereas the others were extubated just after admis
sion to the PACU. Exhaled anesthetic gases were sampled through a 20-m
hose attached to the participating nurses' shoulders (breathing zone)
. We also evaluated nursing exposure to exhaled anesthetic gases durin
g recovery of 15 patients who had been anesthetized with nitrous oxide
. Exposure was quantified with lapel dosimeters. Anesthetic and recove
ry durations were each approximately 1 h, with most patients being tra
cheally extubated in the PACU. Breathing-zone anesthetic concentration
s in the patients given isoflurane exceeded NIOSH recommendations in 3
7% of the patients, representing 12% of recovery time. Breathing-zone
anesthetic concentrations in the patients given desflurane, however, e
xceeded NIOSH limits in 87% of the patients, representing 49% of recov
ery time. Altogether, noncompliant episodes were detected in 68% of th
ese patients, representing 35% of the entire recovery duration. Breath
ing-zone anesthetic concentrations in the patients given nitrous oxide
exceeded NIOSH limits in 53% of the patients. Our data suggest that p
ostoperative nurses' exposure to exhaled anesthetic gases exceeds NIOS
H limits under some circumstances. Implications: Some epidemiological
evidence suggests that exposure to waste anesthetic gases may be assoc
iated with reproductive toxicity. Accordingly, the National institute
of Occupational Safety and Health has established recommended exposure
limits for nitrous oxide and volatile anesthetics. Our data suggest t
hat exposure of healthcare personnel may exceed recommended levels in
poorly ventilated postanesthesia care units.