Psychosocial factors are now established as important contributors to
understanding inequality and change in health. However, their complex
nature creates both assessment and analytic challenges for elucidating
their role in competition with more traditional risk factors (particu
larly in population studies) and serves to limit their adoption. This
article considers these issues as they relate to the measurement and q
uantification of adversity exposure over the life course in the contex
t of a component study to the European Prospective Investigation into
Cancer and Nutrition (EPIC). EPIC is designed primarily to determine t
he extent to which diet diversity across Europe can explain marked var
iation in cancer incidence through longitudinal surveys. This article
illustrates the extent to which psychological adaptation to loss event
experience takes place with increasing time since event occurrence an
d the importance of distinguishing such proximal from distal experienc
es for analysis. A conceptual framework, graphically represented in te
rms of unknown adversity states progressing through time, is discussed
for testing and evaluating the relative importance of different adver
se experiences and of their impact under increasing complexity. (C) 19
98 John Wiley & Sons, Ltd.