BACTERICIDAL ACTIVITIES OF THE PYRROLE DERIVATIVE BM212 AGAINST MULTIDRUG-RESISTANT AND INTRAMACROPHAGIC MYCOBACTERIUM-TUBERCULOSIS STRAINS

Authors
DEIDDA D LAMPIS G FIORAVANTI R BIAVA M PORRETTA GC ZANETTI S POMPEI R
Citation
D. Deidda et al., BACTERICIDAL ACTIVITIES OF THE PYRROLE DERIVATIVE BM212 AGAINST MULTIDRUG-RESISTANT AND INTRAMACROPHAGIC MYCOBACTERIUM-TUBERCULOSIS STRAINS, Antimicrobial agents and chemotherapy, 42(11), 1998, pp. 3035-3037
Citations number
22
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
42
Issue
11
Year of publication
1998
Pages
3035 - 3037
Database
ISI
SICI code
0066-4804(1998)42:11<3035:BAOTPD>2.0.ZU;2-U
Abstract
The pyrrole derivative BM212 [1,5-diaryl-2-methyl-3-(4-methylpiperazin -1-yl) methyl-pyrrole] was shown to possess strong inhibitory activity against both Mycobacterium tuberculosis and some nontuberculosis myco bacteria. BM212 was inhibitory to drug-resistant mycobacteria and also exerted bactericidal activity against intracellular bacilli residing in the U937 human histiocytic lymphoma cell line.