EFFECTS OF CHANGING THE AVAILABILITY OF THE SUBSTRATE FOR NITRIC-OXIDE SYNTHASE BY L-ARGININE ADMINISTRATION ON CORONARY VASOMOTOR TONE IN ANGINA PATIENTS WITH ANGIOGRAPHICALLY NARROWED AND IN PATIENTS WITH NORMAL CORONARY-ARTERIES

Authors
TOUSOULIS D DAVIES GJ TENTOLOURIS C CRAKE T KATSIMAGLIS G STEFANADIS C TOUTOUZAS P
Citation
D. Tousoulis et al., EFFECTS OF CHANGING THE AVAILABILITY OF THE SUBSTRATE FOR NITRIC-OXIDE SYNTHASE BY L-ARGININE ADMINISTRATION ON CORONARY VASOMOTOR TONE IN ANGINA PATIENTS WITH ANGIOGRAPHICALLY NARROWED AND IN PATIENTS WITH NORMAL CORONARY-ARTERIES, The American journal of cardiology, 82(9), 1998, pp. 1110
Citations number
25
Categorie Soggetti
Cardiac & Cardiovascular System
Journal title
The American journal of cardiology → ACNP
ISSN journal
00029149
Volume
82
Issue
9
Year of publication
1998
Database
ISI
SICI code
0002-9149(1998)82:9<1110:EOCTAO>2.0.ZU;2-Q
Abstract
We assessed the effects of intracoronary administration of substance P , LNMMA, L-arginine, and nitroglycerin in patients with normal coronar y angiograms and in patients with coronary artery disease. LNMNIA cons tricted (p <0.01) and both substance P and nitroglycerin dilated norma l and diseased proximal and distal segments and stenoses (p <0.01). L- Arginine reversed the effect of LNMMA in all segments and caused great er dilation of the diseased arteries, including stenoses (p<0.05), ind icating that there is a relative deficiency Of L-arginine in diseased coronary arteries.