BIOHYDROXYLATIONS OF CBZ-PROTECTED ALKYL SUBSTITUTED PIPERIDINES BY BEAUVERIA-BASSIANA ATCC-7159

N-Benzyloxycarbonyl (Cbz) protected piperidines are hydroxylated with greater regioselectivity than the corresponding N-benzoyl analogues wh en incubated with the fungus Beauveria bassiana ATCC 7159. Cbz-protect ed piperidines 1-3, 5-7, have been biotransformed by growing cell susp ensions of this fungus to yield predominantly 4-hydroxylated products in up to 48% yield. The regiospecificity of hydroxylation was only com promised significantly with N-Cbz-3-methylpiperidine 3 and N-Cbz-2-met hylpiperidine 4 where hydroxylation occurred in both the 3 and 4 posit ions.