HEXACHLOROCYCLOHEXANE AND ITS ISOMERS - REGIONAL BRAIN LEVELS IN THE RAT AFTER DERMAL EXPOSURE

In the present study the distribution of hexachlorocyclohexane (HCH) a nd its isomers in the brain of rats given dermal exposure of this pest icide have been investigated using a gas liquid chromatographic techni que. The male Druckery rats were given dermal exposure of HCH 50 or 10 0 mg/kg body weight/day in 0.2 ml acetone for the period of 60 or 120 days. The results reveal that an appreciable quantity of HCH and its i somers alpha, beta, gamma, and delta accumulate in a dose- and time-de pendent manner in different regions of the brain, which may adversely affect the specific physiological function of these brain regions.