PRECLINICAL AND CLINICAL-MODELS OF LUNG-CANCER CHEMOPREVENTION

This article presents an overview of recent progress in the developmen t of chemopreventive agents against human lung cancer. Beta-carotene, retinol, and vitamins E and C appear to have little effect or a negati ve effect against human lung cancer development. New agents that have been shown to inhibit lung tumorigenesis in rodents, such as glucocort icoids, green tea, nonsteroidal anti-inflammatory drugs, and the isoth iocyanates, have not been tested in humans yet. These agents may be mo re effective in preventing human lung cancer in smokers than the chemi cals tested thus far, especially if they are delivered by the inhalati on route.