ANDROGEN-DEPENDENT MODULATION OF CALBINDIN-D-28K IN HYPOTHALAMIC TISSUE DURING PRENATAL DEVELOPMENT

Authors
WATSON MA TAYLOR H LEPHART ED
Citation
Ma. Watson et al., ANDROGEN-DEPENDENT MODULATION OF CALBINDIN-D-28K IN HYPOTHALAMIC TISSUE DURING PRENATAL DEVELOPMENT, Neuroscience research, 32(1), 1998, pp. 97-101
Citations number
21
Categorie Soggetti
Neurosciences
Journal title
Neuroscience research → ACNP
ISSN journal
01680102
Volume
32
Issue
1
Year of publication
1998
Pages
97 - 101
Database
ISI
SICI code
0168-0102(1998)32:1<97:AMOCIH>2.0.ZU;2-P
Abstract
We examined the influence of androgens on fetal medial basal hypothala mic and preoptic area (MBH-POA) calbindin-D-28K levels (via Western an alysis) by treating pregnant rats with testosterone or flutamide, tan androgen receptor blocker). MBH-POA calbindin-D-28K levels were signif icantly decreased in flutamide-treated male fetuses, whereas, MBH-POA calbindin-D-28K levels were significantly increased in testosterone-tr eated female fetuses compared to controls. These results suggest that MBH-POA calbindin-D-28K is modulated during prenatal development by an drogens. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.