DETERMINATION OF STRUCTURE-TOXICITY RELATIONSHIP OF AMPHIPROTIC COMPOUNDS BY MEANS OF THE INHIBITION OF THE DEHYDROGENASE-ACTIVITY OF PSEUDOMONAS-PUTIDA

Aliphatic and aromatic alcohols are amphiprotic compounds which have b oth polar and nonpolar parts in their structure. These compounds were studied with respect to the nonreactive toxic effects on the microorga nism Pseudomonas putida. The toxicity of these chemicals to aerobic ba cterium P. putida was measured in terms of inhibition of dehydrogenase activity. The test results, expressed as concentration of chemicals 5 0% effective in inhibition (IC50), were correlated with their physicoc hemical properties such as aqueous solubility (S) and octanol-water pa rtition coefficient (P).