COMPLEX OF (-)-MORPHINE WITH BETA-PHENYLHYDRACRYLIC ACID

Authors
LUTZ M SPEK AL
Citation
M. Lutz et Al. Spek, COMPLEX OF (-)-MORPHINE WITH BETA-PHENYLHYDRACRYLIC ACID, Acta crystallographica. Section C, Crystal structure communications, 54, 1998, pp. 1477-1479
Citations number
12
Categorie Soggetti
Crystallography
Journal title
Acta crystallographica. Section C, Crystal structure communications → ACNP
ISSN journal
01082701
Volume
54
Year of publication
1998
Part
10
Pages
1477 - 1479
Database
ISI
SICI code
0108-2701(1998)54:<1477:CO(WBA>2.0.ZU;2-K
Abstract
The crystal structure of the complex of (-)-morphine with (S)-beta-phe nylhydracrylic acid, C17H20NO3+. C9H9O3- is reported. There are no maj or differences in the conformation of the piperidine ring of morphine compared with other protonated morphines. The staggered conformation o f the central bond in the free form of beta-phenylhydracrylic acid cha nges to another staggered conformation in the morphine complex. This c onformational change is induced by intermolecular hydrogen bonds.