Introduction: we have tested the hypothesis that the co-occurrence of
common impairments (motor and cognitive impairments, vision and hearin
g loss, depressive symptoms) of later life have exacerbating effects o
n disability [activities and instrumental activities of daily living,
social and role function, (in)activity]. Method: data were drawn from
a community-based sample of 624 people aged 57 and older. Results: mot
or impairments and depressive symptoms were associated with all disabi
lity measures, even when the effects of other impairments, age and gen
der were controlled. This indicates independent, predominant effects o
f motor impairments and depressive symptoms. Although several signific
ant first-order interaction effects (indicating exacerbation) of impai
rments on disability were found, they were not very strong, but vision
and hearing losses exacerbate the impact of the other impairments on
disability. Conclusions: impairments, particularly motor impairments a
nd depressive symptoms, largely act 'solo', by main effects on disabil
ity. Only a few combinations including vision or hearing loss further
exacerbate the effects of other impairments on disability.