POLYMERS IN GENE-THERAPY - ANTISENSE DELIVERY SYSTEMS

Authors
ISRAEL ZH DOMB AJ
Citation
Zh. Israel et Aj. Domb, POLYMERS IN GENE-THERAPY - ANTISENSE DELIVERY SYSTEMS, Polymers for advanced technologies, 9(10-11), 1998, pp. 799-805
Citations number
66
Categorie Soggetti
Polymer Sciences
Journal title
Polymers for advanced technologies → ACNP
ISSN journal
10427147
Volume
9
Issue
10-11
Year of publication
1998
Pages
799 - 805
Database
ISI
SICI code
1042-7147(1998)9:10-11<799:PIG-AD>2.0.ZU;2-U
Abstract
Antisense aligonucleotides can down-regulate or specifically turn off individual genes and have therefore received much attention in the era of gene therapy. while effective in vitro, delivery in vivo has been problematic. This review focusses on the progress of polymeric, non-vi ral methods of antisense delivery and also describes some of the excit ing potential clinical applications of this technology. (C) 1998 John Wiley & Sons, Ltd.