THE EVOLUTION OF CHIRAL STATIONARY PHASES FOR LIQUID-CHROMATOGRAPHY

The development of effective chiral stationary phases (CSPs) and separ ation strategies for the liquid chromatographic (LC) resolution of ena ntiomers has been beneficial to many scientific disciplines. Over the last decade the number and type of CSPs has expanded tremendously. Not only have new classes of chiral selectors been introduced, but also m any of the first CSPs have been changed and/or improved. The second or third generation of a CSP often can be different from the original. T his can be confusing and intimidating to someone just entering the are a of LC enantiomeric separations. Fortunately, all CSPs can be categor ized in one or another of a few classes. There are generally one or tw o columns that can accomplish the majority of separations in each clas s. In this work we look at the different classes of CSPs and how they have expanded and changed over the last decade.