EFFECTS OF RESORBABLE MEMBRANE PLACEMENT AND HUMAN OSTEOGENIC PROTEIN-1 ON HARD-TISSUE HEALING AFTER PERIRADICULAR SURGERY IN CATS

Periradicular surgeries were performed on the maxillary cuspid teeth o f twelve cats. Before reapproximation of the surgical flaps, eight of the osteotomies were covered with a resorbable membrane and eight were filled with human osteogenic protein-1 (hOP-1) on a collagen carrier. The remaining eight sites received no further treatment and sewed as controls. The animals were euthanized after 12 wk, and the specimens w ere examined histomorphometrically for the presence or absence of osse ous regeneration, inflammation, and cementum formation on the root end s. The results showed that the sites treated with the membrane exhibit ed significantly move inflammation adjacent to the resected root ends (p < 0.05), and that the use of the membrane had no statistically sign ificant effect on osseous healing or new cementum formation. The use o f hOP-1 was associated with a significant decrease in the thickness of new cementum formed on the resected root ends (p < 0.05), but had no statistically significant effect on osseous healing or degree of infla mmation. Based on these results, it seems that neither the use of hOP- 1 nor resorbable membranes have a positive effect on periradicular tis sue healing in endodontic surgery.