ANGIOTENSIN-CONVERTING ENZYME-INHIBITOR ENALAPRIL IN PATIENTS WITH ESSENTIAL-HYPERTENSION - ANTIHYPERTENSIVE EFFICACY (24-HOUR BLOOD-PRESSURE MONITORING DATA), SAFETY AND EFFECT ON MORPHOFUNCTIONAL PARAMETERS OF THE HEART

The paper presents clinical data and results of 24-hour blood pressure monitoring of 31 patients with mild to moderate hypertension treated with enalapril (5 - 20 mg/day) for 16 weeks. Efficacy monotherapy with enalapril was 67.7% and it was increased up to 83,9% by addition of h ydrochlorothiazide. Side effects characteristic of angiotensin convert ing enzyme inhibitors were observed in 9,7% of patients. Long term the rapy with enalapril lowered average 24-hour systolic and diastolic pre ssures by 10,5 and 8,1%, respectively. There was no significant change of left ventricular myocardial contractile function while total perip heral resistance significantly decreased by 15,6%. Myocardial mass als o decreased (by 3,4%).