VITAL DIAGNOSIS OF CREUTZFELDT-JACOB-DISEASE

The paper presents the data concerning usage of some original method o f vital laboratory diagnostics of Creutzfeldt-Jacob disease that belon gs to the group of prionic diseases. The method consisted in the inocu lation of inoculative culture of rat Gasser ganglion's neurinoma by bi ologic materials investigated (serum and clot of blood) with the follo wing passivation and investigation of the contaminated culture by mean s of both morphologic and electron microscopic methods. As an example of vital verificated case the wide pathomorphologic analysis of the bi opsy sample of brain was presented. Besides, the efficiency of the inv estigation of cognitive evoked potentials (P300) together with EEG was also demonstrated as the method of objectification of the development of dementia in this disease.