CYTOGENETIC ANALYSIS OF 11 RENAL ONCOCYTOMAS - FURTHER EVIDENCE OF STRUCTURAL REARRANGEMENTS OF 11Q13 AS A CHARACTERISTIC CHROMOSOMAL ANOMALY

We carried out cytogenetic analysis on 11 renal oncocytomas by using G -banding and DAPI-banding techniques Four of our tumors exhibited stru ctural rearrangements affecting chromosome 11 at band q13. Together wi th another case previously described by us, our tumors constitute the largest series of renal oncocytomas displaying translocations involvin g 11q13. A review of the literature disclosed only 6 similar oncocytom as, 1 tumor with a t(9;11)(p23;q12), 2 tumors with a nearly identical t(9;11)(p23;q13), and 3 tumors with a t(5;11)(q35;q13). Therefore, our findings provide further cytogenetic evidence that genes located on 1 1q12-13 may be involved in the tumorigenesis of renal oncocytomas. (C) Elsevier Science Inc., 1998.