MYELODYSPLASTIC SYNDROME WITH HYPEREOSINOPHILIA AND A NONRANDOM CHROMOSOMAL ABNORMALITY DIC(1-7) - CONFIRMATION OF EOSINOPHIL CLONAL INVOLVEMENT BY FLUORESCENCE-IN-SITU-HYBRIDIZATION

We report a case of de novo myelodysplastic syndrome (MDS) with hypere osinophilia and dic(1;7) in which eosinophil clonal involvement was co nfirmed by fluorescence in situ hybridization. There have been two pre vious reports in the literature of eosinophilic MDS with dic(1;7) or t (1;7) in which eosinophil clonality was demonstrated. The specific bre akpoints on chromosomes 1 and 7 differ in the three cases, making it d ifficult to implicate disruption of a single gene as causative; nevert heless, the nonrandom occurrence of t(1;7) or dic(1;7) with malignant eosinophilic proliferations suggests that this chromosomal rearrangeme nt is involved in the etiology of the disease. (C) Elsevier Science In c., 1998.