NONPEPTIDIC CORTICOTROPIN-RELEASING HORMONE-RECEPTOR TYPE-1 ANTAGONIST REVERSES RESTRAINT STRESS-INDUCED SHORTENING OF SODIUM PENTOBARBITAL-INDUCED SLEEPING TIME OF RATS - EVIDENCE THAT AN INCREASE IN AROUSAL INDUCED BY STRESS IS MEDIATED THROUGH CRH RECEPTOR-TYPE-1

Authors
ARAI K OHATA H SHIBASAKI T
Citation
K. Arai et al., NONPEPTIDIC CORTICOTROPIN-RELEASING HORMONE-RECEPTOR TYPE-1 ANTAGONIST REVERSES RESTRAINT STRESS-INDUCED SHORTENING OF SODIUM PENTOBARBITAL-INDUCED SLEEPING TIME OF RATS - EVIDENCE THAT AN INCREASE IN AROUSAL INDUCED BY STRESS IS MEDIATED THROUGH CRH RECEPTOR-TYPE-1, Neuroscience letters, 255(2), 1998, pp. 103-106
Citations number
18
Categorie Soggetti
Neurosciences
Journal title
Neuroscience letters → ACNP
ISSN journal
03043940
Volume
255
Issue
2
Year of publication
1998
Pages
103 - 106
Database
ISI
SICI code
0304-3940(1998)255:2<103:NCHTA>2.0.ZU;2-8
Abstract
Stress shortens sodium pentobarbital (PbNa)-induced sleeping time thro ugh corticotropin-releasing hormone (CRH) in rats. We investigated whe ther this effect of brain CRH is mediated by CRH receptor type 1 (CRHR 1) using a non-peptidic CRHR1 antagonist in rats. A 60 min period of r estraint significantly shortened PbNa-induced sleeping time. This shor tening was completely reversed by peripheral administration of CRHR1 a ntagonist. These results suggest that the stress-induced increase in a rousal is mediated by CRHR1. (C) 1998 Elsevier Science Ireland Ltd. Al l rights reserved.