EVALUATION OF THE ENANTIOSELECTIVE POSSIBILITIES OF SULFATED CYCLODEXTRINS FOR THE SEPARATION OF ASPARTYL DIPEPTIDES AND TRIPEPTIDES IN CAPILLARY-ELECTROPHORESIS

Highly sulfated alpha-, beta- and gamma-cyclodextrins were used to inv estigate the simultaneous separation of isomeric alpha- and beta-aspar tyl containing di- and tripeptides as well as their enantiomers in cap illary electrophoresis. Separation of the enantiomers was accomplished with the different sulfated cyclodextrin types under acidic condition s (pH 2-3). In some cases, comigration of diastereomerically related i somers or epimers resulted in incomplete separations. The results obta ined with the highly sulfated cyclodextrins, having an average degree of substitution 12, were compared to those obtained with sulfated cycl odextrins with degree of substitution 4. (C) 1998 Elsevier Science B.V . All rights reserved.