GLUCURONIC-ACID CONJUGATES

The methods of assay in body fluids of 1-beta-alkyl, 1-beta-phenyl and 1-beta-acyl glucuronic acids (''glucuronide conjugates'') have been r eviewed. Most of the 78 references cited (from the literature of the p eriod 1990-1997) concern the glucuronide conjugates of drug metabolite s, and these have been considered, for reasons of accessibility, withi n sections of individual drug classes such as analgesics, anti-cancer agents and opioids. Other glucuronide conjugates are considered under ''miscellaneous compounds''. A few gas chromatography and capillary el ectrophoresis methods are described, but the major technique of assay (62 citations) is reversed-phase high-performance liquid chromatograph y. (C) 1998 Published by Elsevier Science B.V. All rights reserved.