DIASTEREOSELECTION IN THE CONJUGATE ADDITIONS OF ORGANOCOPPER REAGENTS TO N-ENOYLOXAZOLIDINONES

Authors
WILLIAMS DR KISSEL WS LI JJ
Citation
Dr. Williams et al., DIASTEREOSELECTION IN THE CONJUGATE ADDITIONS OF ORGANOCOPPER REAGENTS TO N-ENOYLOXAZOLIDINONES, Tetrahedron letters, 39(47), 1998, pp. 8593-8596
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
47
Year of publication
1998
Pages
8593 - 8596
Database
ISI
SICI code
0040-4039(1998)39:47<8593:DITCAO>2.0.ZU;2-M
Abstract
A survey of conjugate additions of Yamamoto organocopper reagents to N -enoyl-4-substituted oxazolidinones is reported. Diastereofacial selec tivity is reversed for 4-phenyl and 4-benzyloxazolidinones of the same relative configuration. Alkenylcopper reagents demonstrate superior r esults in asymmetric additions using the 4-phenyloxazolidinone auxilia ry. (C) 1998 Elsevier Science Ltd. All rights reserved.