SYNTHESIS AND BIOLOGICAL EVALUATION OF FULLY SYNTHETIC BRYOSTATIN ANALOGS

Authors
WENDER PA DEBRABANDER J HARRAN PG HINKLE KW LIPPA B PETTIT GR
Citation
Pa. Wender et al., SYNTHESIS AND BIOLOGICAL EVALUATION OF FULLY SYNTHETIC BRYOSTATIN ANALOGS, Tetrahedron letters, 39(47), 1998, pp. 8625-8628
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
47
Year of publication
1998
Pages
8625 - 8628
Database
ISI
SICI code
0040-4039(1998)39:47<8625:SABEOF>2.0.ZU;2-0
Abstract
The first members of a new class of designed bryostatin analogues are synthesized using a novel, convergent macrotransacetalization strategy . These simplified analogues, lacking the A-ring of bryostatin 1 and p ossessing a simplified B-ring, exhibit significant protein kinase C bi nding affinities and growth inhibitory activities against several huma n cancer cell lines. (C) 1998 Elsevier Science Ltd. All rights reserve d.