SYNTHESIS OF ARTIFICIAL GLYCOCONJUGATE POLYMERS CARRYING BIOLOGICALLY-ACTIVE TRISACCHARIDES WITH ALPHA-D-GALACTOPYRANOSYL (1-]3) AND (1-]4)-LINKAGE

Authors
NISHIDA Y DOHI H UZAWA H KOBAYASHI K
Citation
Y. Nishida et al., SYNTHESIS OF ARTIFICIAL GLYCOCONJUGATE POLYMERS CARRYING BIOLOGICALLY-ACTIVE TRISACCHARIDES WITH ALPHA-D-GALACTOPYRANOSYL (1-]3) AND (1-]4)-LINKAGE, Tetrahedron letters, 39(47), 1998, pp. 8681-8684
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
47
Year of publication
1998
Pages
8681 - 8684
Database
ISI
SICI code
0040-4039(1998)39:47<8681:SOAGPC>2.0.ZU;2-L
Abstract
Starting from p-nitrophenyl-beta-lactoside, two types of neoglycoconju gate carrying either a trisaccharide segment of globotriaosyl ceramide (Gb3) or its regioisomeric Gal alpha 1,3Gal beta 1,4Glc were synthesi zed via a common intermediate. The former polymer carrying the Gb3 tri saccharide showed strong neutralization activity against Shiga-like to xin-I in the assay using human ACHN cells. (C) 1998 Elsevier Science L td. All rights reserved.