INCREASED LIPOPEROXIDE LEVELS AND ANTIOXIDANT SYSTEM IN COLORECTAL-CANCER

In this study, lipid peroxide and glutathione (GSH) levels, GSH peroxi dase, GSH S-transferase, superoxide dismutase, gamma-glutamylcysteine synthetase and gamma-glutamyl transpeptidase activities were investiga ted in tumorous and nontumorous colorectal tissues obtained from ten p atients diagnosed with colon and rectum cancer. Histopathological eval uations, including type, stage, necrosis and lymphocyte infiltration, were also performed for each patient. According to the results, lipid peroxide and GSH levels and the activities of GSH peroxidase, superoxi de dismutase, gamma-glutamylcysteine synthetase were found to be incre ased, while GSH S-transferase and gamma-glutamyl transpeptidase activi ties remained unchanged in tumors compared to adjacent normal tissues of subjects with colorectal cancer. However, the considerable interind ividual variations were found in these parameters. A definite interrel ation between histopathological results with lipid peroxidation and an tioxidant system was not observed.