CANCER IN ACROMEGALY

In recent years, it has become increasingly recognized that acromegaly predisposes to a variety of cancers, particularly colorectal and brea st cancers, and perhaps haematological malignancies. However, these as sociations haze been based mostly on small epidemiological surveys, an d a propensity towards other malignancies might also become apparent i n the future. This review assesses these three malignancies together w ith those of the thyroid and pi-estate, and discusses their pathogenes is, concentrating on the role of the growth hormone/insulin-like growt h factor I (IGF-I) axis.