EFFECT OF TABLETING CONDITIONS ON THE STICKING OF TABLET USING IBUPROFEN

Influence of tableting conditions on sticking was investigated using t wo formulations, the one formulation containing ibuprofen (formulation A) and the other being the standard formulation (formulation B). Stic king was observed on formulation A, and was not observed on formulatio n B. The degree of sticking was decreased with increase in compression pressure, and increased with compression speed. The shape of punch fa ce was influenced the degree of sticking (sugar concave < bebel < flat ). It was thought that sticking was observed when the adhesion between tablet and punch was larger than that among tableting granules. We in vestigated the pressure placed on a scraper (SCR), the adhesion betwee n granules and metal, and boring hardness of tablet. The results showe d that sticking was not observed when the SCR and/or the adhesion were small enough or boring hardness of tablet was high enough. Furthermor e, it was suggested that boring hardness distribution would influence sticking.