R. Rodriguezabad et J. Tsibouklis, UNSYMMETRICALLY SUBSTITUTED ALIPHATIC DIACETYLENES CONTAINING AMINE FUNCTIONALITIES, Synthetic communications, 28(23), 1998, pp. 4333-4338
A one-pot reaction which combines the Cadiot-Chodkiewicz coupling reac
tion with the Gabriel synthesis of primary amines is evaluated as a me
ans for the synthesis of unsymmetrically disubstituted aminodiacetylen
es of the type CH2-(CH2)(n)C=C-C=C-CH2-NH2 (n=2,3,4,5).