AN EFFECTIVE AND CONVENIENT ESTERIFICATION OF CEPHALOSPORIN DERIVATIVES BY USING QUARTERNARY AMMONIUM-SALTS AS CATALYSTS

Authors
LEE HW KANG TW KIM EN SHIN J CHA KH CHO DO CHOI NH KIM JW HONG CI
Citation
Hw. Lee et al., AN EFFECTIVE AND CONVENIENT ESTERIFICATION OF CEPHALOSPORIN DERIVATIVES BY USING QUARTERNARY AMMONIUM-SALTS AS CATALYSTS, Synthetic communications, 28(23), 1998, pp. 4345-4354
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthetic communications → ACNP
ISSN journal
00397911
Volume
28
Issue
23
Year of publication
1998
Pages
4345 - 4354
Database
ISI
SICI code
0039-7911(1998)28:23<4345:AEACEO>2.0.ZU;2-U
Abstract
A method for preparing cephalosporin derivatives by reacting cephalosp orin alkaline metal salts with organic halide in the presence of quart ernary ammonium salts catalyst is disclosed. Delta(3) to Delta(2) isom erization, a side reaction commonly reported in preparation of cephalo sporin derivatives, was successfully eliminated. The desired Delta(3) was obtained as a sole product in the reaction.