NOSOLOGICAL AND GENETIC-ASPECTS OF ASPERGER-SYNDROME

The validity of Asperger syndrome (i.e., apart from high-functioning a utism) continues to be the topic of considerable debate. Consistent wi th Asperger's original description of the condition there appear to be some important potential differences from autism if both conditions a re strictly defined. Although the importance of genetic factors in the transmission of autism is increasingly clear it also appears that gen etic factors may play an even more important role in Asperger syndrome (AS). The nosological validity of this condition and its relation to the various PDD spectrum disorder remains an important topic for futur e research. Well-designed and carefully controlled studies are needed in which patterns of comorbidity and associated problems in family mem bers can be carefully assessed. Such studies will contribute to our un derstanding of the relationship of AS and autism and may clarify impor tant genetic mechanisms of relevance to autism.