HEMODYNAMIC AND METABOLIC FACTORS OF LOWE RING OF PHYSICAL WORKING CAPACITY IN PATIENTS WITH ISCHEMIC-HEART-DISEASE AND TYPE-II DIABETES

Exercise tests and biochemical studies were done in 43 patients with i schemic heart disease and postinfarction cardiosclerosis and in 27 pat ients with compensated non-insulin-dependent diabetes. Control group c onsisted of 52 healthy persons. In both groups of patients parameters of physical working capacity (maximal work load, total amount of work performed, maximal oxygen consumption) were lowered. Common features i n genesis of these disturbances were decreased cardiac chronotropic re serve, diminished oxygen consumption during exercise, and diastolic ar terial hypertension. In patients with ischemic heart disease elevated levels of lactate and pyruvate were found indicative of activation of glycolytic and oxidative glucose transformation. Adaptational resettin g of hormonal and metabolic status in patients with non-insulin-depend ent diabetes manifested in elevation of levels of insulin, pyruvate an d lactate leading to hyperstimulation of anaerobic sources of energy.