INHIBITING THE DIMERIZATION OF HIV-1 PROTEASE

Disrupting protein-protein interactions in multi-subunit enzymes is cu rrently an underutilized mode of inhibition, and little information ex ists to assist the researcher in the design of agents to effect such a change within the enzyme. This work seeks to address these limitation s by providing a general strategy for the design of dimerization inhib itors of the therapeutically significant enzyme HIV-1 protease.